{"id":118788,"date":"2020-08-21T18:17:24","date_gmt":"2020-08-21T21:17:24","guid":{"rendered":"https:\/\/experienciadevida.com.ar\/portalurbano\/?p=118788"},"modified":"2020-08-21T18:17:24","modified_gmt":"2020-08-21T21:17:24","slug":"por-que-el-sistema-inmune-no-puede-contra-el-coronavirus","status":"publish","type":"post","link":"https:\/\/experienciadevida.com.ar\/portalurbano\/por-que-el-sistema-inmune-no-puede-contra-el-coronavirus\/","title":{"rendered":"\u00bfPor qu\u00e9 el sistema inmune no puede contra el coronavirus?"},"content":{"rendered":"

Un equipo de investigadores de la UNLP logr\u00f3 determinar los mecanismos por los que el virus es capaz de evadir las respuestas inmune innata en los seres humanos.<\/h2>\n
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Un equipo de investigadores de la\u00a0Universidad Nacional de La Plata<\/strong>\u00a0logr\u00f3 determinar los mecanismos por los que\u00a0el coronavirus es capaz de evadir la respuesta inmune innata en los seres humanos<\/strong>\u00a0y c\u00f3mo es que se producen algunos de los efectos colaterales de la enfermedad, como el s\u00edndrome respiratorio agudo severo (SARS).<\/p>\n

Seg\u00fan informaron desde la UNLP y el Conicet, este conocimiento puede ayudar a\u00a0disminuir los efectos perjudiciales y las secuelas de la infecci\u00f3n y tambi\u00e9n podr\u00eda usarse para dise\u00f1ar virus atenuados para el desarrollo de vacunas.<\/strong><\/p>\n

Los descubrimientos se hicieron en el Laboratorio de Biolog\u00eda de Sistemas del Centro Regional de Estudios Gen\u00f3micos (CREG) y determina que la Covid-19 tiene un\u00a0mecanismo viral que le permite regular la expresi\u00f3n de genes de las c\u00e9lulas invadidas y as\u00ed controlar su respuesta inmune.<\/strong><\/p>\n

El aporte fundamental que acaba de hacer el estudio consiste en la descripci\u00f3n de este nuevo mecanismo de interacci\u00f3n entre SARS-Cov-2, el virus responsable de la infecci\u00f3n, y las c\u00e9lulas que ataca. El hallazgo de los investigadores Luis Diambra y Andr\u00e9s Alonso se public\u00f3 este jueves en la revista Frontiers in Cell and Developmental Biology, y es\u00a0uno de los primeros trabajos argentinos sobre el tema en ser reportado internacionalmente.<\/strong><\/p>\n

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En di\u00e1logo con T\u00e9lam, Diambra explic\u00f3 que “hay un mecanismo nuevo que no estaba documentado que es que\u00a0el virus para replicarse consume algunos elementos que tiene la c\u00e9lula que es invadida<\/strong>\u00a0y que es usada por la propia c\u00e9lula para fabricar sus propias prote\u00ednas”.<\/p>\n

“Como el virus no tiene maquinaria para replicarse y fabricar sus prote\u00ednas usa la de las c\u00e9lulas.\u00a0Ese uso agota algunos ingredientes que tiene la c\u00e9lula para fabricar sus propias prote\u00ednas<\/strong>“, grafic\u00f3. Precis\u00f3 que en base a datos que publicaron otros laboratorios “nos fijamos qu\u00e9\u00a0prote\u00ednas de las c\u00e9lulas estar\u00edan comprometidas en funci\u00f3n de que gastaron sus insumos”.<\/p>\n

El cient\u00edfico le dijo a T\u00e9lam que entre esas prote\u00ednas\u00a0“est\u00e1n algunas vinculadas a la inmunidad<\/strong>, y por eso se podr\u00eda explicar por qu\u00e9 el virus evade al sistema inmune”.\u00a0Agreg\u00f3 que, adem\u00e1s, lograron descubrir que\u00a0las otras prote\u00ednas comprometidas “son las que tienen que ver con la regulaci\u00f3n de la inflamaci\u00f3n\u00a0<\/strong>y por eso se ve que en los pacientes graves hay dos s\u00edntomas caracter\u00edsticos: las coagulopat\u00edas y la hiperinflamaci\u00f3n”.<\/p>\n

“Esas dos caracter\u00edsticas podr\u00edan explicarse a trav\u00e9s de una disminuci\u00f3n de una mol\u00e9cula que se llama Alfa 2 macroglobulina”, puntualiz\u00f3 en referencia a la prote\u00edna que funciona como anticoagulante. Diambra detall\u00f3, tambi\u00e9n, que el estudio que realizaron en el laboratorio “tiene importancia desde el punto de vista de ver c\u00f3mo se genera la patolog\u00eda que provoca el virus, y por qu\u00e9 faltan prote\u00ednas”.<\/p>\n

Agreg\u00f3 que esa informaci\u00f3n “podr\u00eda ser utilizada tambi\u00e9n para recodificar el genoma del coronavirus y fabricar vacunas con virus atenuados que son una de las estrategias que se analizan”.\u00a0“Es decir que\u00a0el virus tenga capacidad de infectar pero no tenga la efectividad y no produzca los efectos colaterales<\/strong>\u00a0que tiene, porque lo que mata a los pacientes graves es la hiperinflamaci\u00f3n”, destac\u00f3.\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Un equipo de investigadores de la UNLP logr\u00f3 determinar los mecanismos por los que el…<\/p>\n","protected":false},"author":1,"featured_media":118789,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":""},"categories":[39],"tags":[],"nelio_content":{"isAutoShareEnabled":false,"autoShareEndMode":"default","automationSources":{"useContentSentences":true,"useSocialTemplates":true,"useCustomSentences":false,"customSentences":[]},"followers":[1],"suggestedReferences":[],"includedReferences":[],"efiUrl":"","efiAlt":"","highlights":[]},"yoast_head":"\n\u00bfPor qu\u00e9 el sistema inmune no puede contra el coronavirus? -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/experienciadevida.com.ar\/portalurbano\/por-que-el-sistema-inmune-no-puede-contra-el-coronavirus\/\" \/>\n<meta property=\"og:locale\" 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